The TruHealth Test provides a comprehensive assessment of functional, nutritional and systemic health using advanced epigenetic analysis. It measures over 110 epigenetic biomarker proxies derived from DNA methylation patterns, offering insight into long-term biological function rather than a single snapshot in time.
Unlike traditional blood tests that reflect short-term status, epigenetic biomarkers reveal the cumulative effects of nutrition, metabolism, inflammation, stress and environmental exposure on cellular health.
Why this test is useful
Your DNA methylation patterns reflect how lifestyle, environment, and nutrition influence biological systems over time. TruHealth translates these patterns into clinically relevant biomarker proxies that relate to nutrient status, metabolic balance, immune activity, detoxification capacity, brain health and energy production.
This test is designed to support personalised health optimisation, preventive care and chronic condition management by identifying functional imbalances that may not yet appear on routine blood testing.
How the test works
You collect a blood sample at home using the kit provided.
The sample is returned to the laboratory, where DNA is extracted and analysed for methylation signatures. These signatures are processed using validated epigenetic models that act as proxies for clinical lab biomarkers, metabolomic markers and proteomic indicators.
Results are delivered in a detailed report highlighting key areas of biological function.
What is measured
TruHealth assesses epigenetic proxies across multiple core systems, including:
vitamin and micronutrient status
amino acid balance
lipid metabolism and cardiovascular markers
glucose regulation and metabolic health
immune and inflammatory activity
brain and neurocognitive health
stress, adrenal, and cortisol signalling
detoxification and environmental exposures
mitochondrial and energy production pathways
Biomarkers assessed
This test includes epigenetic proxies for a wide range of markers, including:
Vitamins and nutrients
Vitamin A, Vitamin B2, Vitamin B3, Vitamin B5, Vitamin B6, Vitamin B8 (Inositol), Myoinositol, Vitamin C, Vitamin D, Vitamin E, Choline, Betaine
Amino acids and metabolites
Methionine, Cysteine, Taurine, Glutamine, Arginine, Tyrosine, Glycine, Creatine, Spermidine
Minerals and electrolytes
Iron (Transferrin), Magnesium, Potassium, Calcium, Copper (Ceruloplasmin)
Fatty acids and lipids
Omega 3, Omega 6, DHA, EPA, Triglycerides, LDL-C, HDL-C, ApoB, ApoA1
Glucose and metabolic health
Glucose, HbA1c, Fat burning marker (Palmitoylcarnitine), Satiety hormone (DNAm Leptin)
Immune and inflammation markers
White blood cell count, CRP, IL-6, Neutrophil to lymphocyte ratio, Systemic immune-inflammation index
Brain and neurocognitive markers
Neurogranin, Quinolinate, Dopamine metabolites, Progranulin
Stress and adrenal markers
Cortisol, Chronic stress marker (Kynurenine), Adrenal activity marker (VMA)
Environmental and toxin exposure proxies
PFAS (PFOS and PFOA), Glyphosate, Lead exposure predictor, Air pollution markers, Smoking and oxidative stress markers
Energy and mitochondrial markers
ATP synthase subunit beta, Electron transfer flavoprotein, DRP1, Beta-hydroxybutyrate, Acetoacetate
Who should consider this test
This test may be useful if you:
want advanced insight into nutritional status beyond standard blood tests
are managing chronic health conditions
want to optimise metabolic, immune, or brain health
are interested in preventive and longevity-focused care
want to understand long-term impacts of lifestyle and environmental exposure
are a clinician seeking deeper functional health data
The test is suitable for adults aged 18 years and over.
Understanding your results
Results highlight functional strengths and vulnerabilities across multiple systems. Findings may suggest areas where targeted nutrition, lifestyle or detoxification strategies could be beneficial.
Epigenetic biomarker proxies reflect biological trends and risk patterns, rather than diagnoses.
Results are best interpreted alongside clinical context, symptoms, and health goals.
Returning samples to the lab
It is the user’s responsibility to organise sample returns.
Instructions are provided in the sample collection kit along with a pre-paid return envelope.
Results timeframe
Results are typically available within 3–6 weeks.
Timeframe begins once the laboratory receives your sample.
Important limitations
This test provides predictive functional insights but does not diagnose medical conditions.
Results may be influenced by genetics, lifestyle, environment and age.
Results should not be used to make medical decisions without appropriate professional guidance.
Testing is performed by TruDiagnostic, a HIPAA-compliant and CLIA-certified laboratory specialising in epigenetic testing and research.
TruHealth uses Epigenetic Biomarker Proxies (EBPs) developed from DNA methylation analysis. Over 1,600 validated proxy models were trained across cohorts of more than 30,000 individuals, with demonstrated relevance to chronic disease outcomes and mortality over a 15-year follow-up period.
Price includes shipping cost.
***Purchasing this test means you agree to our stated Terms and Conditions and that you understand it is your responsibility to follow up results with your doctor / general practitioner / medical consultant or healthcare practitioner.***